Therapeutic indications · Reparative and regenerative processes
For the doctor following tissue injury and suffering — in surgery, dermatology, orthopedics, sports medicine — when repair times affect the entire pathway, and consider a complementary, non-invasive, drug-free option. On this page: what exists, what has been studied, with what limits.
In practice
In some patients, tissue repair proceeds more slowly than the injury would have predicted: wounds and ulcers that are difficult to close, muscle and tendon injuries that do not consolidate, edema and inflammation that persist beyond the expected time.
When it happens, the path stretches for everyone: more dressings and controls, delay in rehabilitation, functional and aesthetic outcomes that the patient lives as definitive. And the tools that directly affect repair processes remain few.
It is in this space that it makes sense to consider a complementary – non-invasive – option, applicable on intact skin alongside the standard treatment, with protocols defined by tissue type and depth.
What exists
For the reparative and regenerative processes, REAC® Technology provides the biomodulation protocols of the Tissue Optimization family, applied with the medical device BENE Mod 110. The scope, as defined in the technical documentation, includes conditions characterised by impaired tissue recovery and regeneration capacity in tissue injury and suffering.
Surface application with the ACP electrode on the area to be treated, 15 or 30 minutes per session according to the clinical picture, in cycles of an average of 18 sessions. For the reparative processes of medium and deep tissues with prevalence of the inflammatory component. Reserved for doctors.
Applicazione di superficie con l'elettrodo ACP sulla zona da trattare, 15 minuti per seduta, in cicli mediamente di 18 sedute. Per i processi riparativi in cui prevalgono alterazioni infiammatorie, microcircolatorie o metaboliche; secondo la documentazione tecnica è la modalità consigliata nei processi infiammatori acuti. Riservati ai medici.
Gli stessi tre protocolli nella variante da 30 minuti per seduta, in cicli mediamente di 9 sedute: secondo la documentazione tecnica è la modalità consigliata nei processi infiammatori cronici. Stessa applicazione di superficie con l'elettrodo ACP. Riservati ai medici.
The treatment is painless and takes place on intact skin; according to the technical documentation, no contraindications to the concomitant use of pharmacological therapies are known.
What literature says
Eleven clinical publications by Rinaldi and Fontani (2011–2026) on reparative processes, plus in vitro and animal model studies, are indexed on PubMed. These include: a three-arm randomized trial, a prospective observational post-market clinical follow-up study, an interventional study without control group, and several case reports. Here the main ones, with design and number.
Acta Dermatovenerologica Alpina, Pannonica et Adriatica · 2020
Randomized, controlled, prospective, three-armed · 30 patients with venous ulcers of the lower extremities · TO-RPR in addition to the standard dressing, with or without elastic compression, against dressing and compression alone · healing, perceived pain, quality of life.
View on PubMed →Journal of Clinical Medicine · 2026
Prospective observational (PMCF), without control group · 50 subjects in routine clinical practice · ACT, CO and MO in sequence · pain (VAS) at initiation, end of treatment and follow-up; sleep, fatigue and general perceived state by severity categories · no adverse events reported.
View on PubMed →Heliyon · 2020
Interventional, without control group · 45 subjects with acute medial collateral ligament injury of the knee · one NPO session and 18 TO sessions within 4 days of trauma · clinical evaluation at four time points, 30-day follow-up · comparison only with usual practice times.
View on PubMed →Cureus · 2025
Case report · a 22-year-old patient · 18 TO-RPR sessions · pain (NRS), joints, strength; MRI at 4 months.
View on PubMed →The limits to know: The only randomized trial had 30 patients divided into three groups. the PMCF study has no control group and is conducted by the inventors of the technology; the rest of the clinical literature is made up of case reports and small series; in vitro and animal model studies document mechanisms, not clinical outcomes.
Frequently Asked Questions
As a complementary option: in studies, the TO-RPR protocol is applied in addition to the standard dressing and, in musculoskeletal lesions, alongside the rehabilitation pathway. According to the technical documentation, no contraindications to the concomitant use of pharmacological therapies are known. Evaluation, treatment selection and judgment on outcomes remain with the doctor.
La documentazione tecnica distingue per tessuto, componente prevalente e fase: TO-RPR per i tessuti medi e profondi con componente infiammatoria; ACT, CO e MO quando prevalgono alterazioni infiammatorie, microcircolatorie o metaboliche, nella versione da 15 minuti consigliata nei processi infiammatori acuti o nella variante IBZ da 30 minuti consigliata nei processi infiammatori cronici. La scelta è del medico, sulla base dell'inquadramento clinico.
15-minute sessions (ACT, CO, MO) or 15-30-minute sessions (TO-RPR), in cycles of an average of 18 sessions; IBZ variants involve sessions of 30 minutes in cycles of an average of 9. The sessions are spaced at intervals of at least one hour and at most two weeks.
Treatment is contraindicated in established or suspected pregnancy, in carriers of pacemakers or other active implantable devices, and in the presence of injured skin, sores, ulcers or infections in the area of application. The expected side effects reported in the technical documentation for biomodulation protocols — in about one in ten patients — are localised tenderness and asthenia, resolving spontaneously.
A discussion with technical-scientific support to examine relevant protocols, technical documentation and publications, and understand how it fits into the workflow. The pathway includes initial training and ongoing assistance: Route and Support.
The indications of use, contraindications and warnings of REAC® devices are only those indicated in the technical documentation and in the instructions for use, in accordance with the regulatory framework for medical devices. This page describes the areas of application documented, without constituting a promise of clinical outcome.
Let's talk about it with technical and scientific support: an assessment, without obligation.
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EnterFor information on treatments you can contact the Rinaldi Fontani Institute in Florence.
Go to irf.itLegislative Decree No 46 of 24 February 1997 — Article 21